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    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park et al.
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann et al.
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

    Susanne CS Bantele et al.
    Chromatin remodelling is a key bottleneck to DNA end resection, the first and committed step of homologous recombination.
    1. Neuroscience

    Convergence of cortical types and functional motifs in the human mesiotemporal lobe

    Casey Paquola et al.
    A novel model of the human mesiotemporal lobe suggests that its broad roles in cognition can be explained by how its cytoarchitecture and form relate to large-scale functional motifs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha et al.
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Physics of Living Systems

    Phylodynamic theory of persistence, extinction and speciation of rapidly adapting pathogens

    Le Yan et al.
    A model of pathogen co-evolving with host population continuously acquiring immunity is used to identify evolutionary parameters allowing pathogen population to persist without going extinct or splitting into independent lineages.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Global morphogenetic flow is accurately predicted by the spatial distribution of myosin motors

    Sebastian J Streichan et al.
    Epithelial tissue remodeling during Drosophila embryonic development is quantitatively described by a simple law relating myosin activity and cell flow.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

    Ulrike Künzel et al.
    The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.
    1. Neuroscience

    Calcium imaging with genetically encoded indicators in behaving primates

    Eyal Seidemann et al.
    The link between the activity of large populations of cortical neurons and single neuron responses is examined in primates using a new optical-genetic method.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Puromycin reactivity does not accurately localize translation at the subcellular level

    Syed Usman Enam et al.
    Methods that use puromycin to localize active translation do not actually detect the site of translation.