154 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A general strategy to construct small molecule biosensors in eukaryotes

    Justin Feng et al.
    A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast, mammalian cells and plants.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.
    1. Biochemistry and Chemical Biology

    Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides

    Olivier Sallin et al.
    A family of fluorescent biosensors for nicotinamide adenine dinucleotides allows quantification of these cofactors in live cells with spatio-temporal resolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Single-color, ratiometric biosensors for detecting signaling activities in live cells

    Brian L Ross et al.
    A novel panel of homoFRET biosensors that detect kinase and second messenger activity, called FLAREs, enables multiparameter imaging of signaling activities within a single live cell with a quantitative and ratiometric readout.
    1. Cell Biology

    A novel biosensor to study cAMP dynamics in cilia and flagella

    Shatanik Mukherjee et al.
    A new FRET-based cAMP biosensor with nanomolar sensitivity makes it possible to measure cAMP dynamics in miniscule subcellular compartments like cilia and flagella.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

    Kathryn E Livingston et al.
    Opioid drug efficacy and allosteric modulation is measured using an active state sensor of the mu-opioid receptor.
    1. Cell Biology
    2. Plant Biology

    Biosensors: Plant biologists FRET over stress

    Won-Gyu Choi, Simon Gilroy
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    1. Plant Biology

    Transport Proteins: Getting to grips with ammonium

    Yi Wang, Jonathan A Javitch
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    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele et al.
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.

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