1,035 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Connectivity map of bipolar cells and photoreceptors in the mouse retina

    Christian Behrens et al.
    A quantitative analysis of the connectivity between photoreceptors and bipolar cells in the mouse retina based on electron microscopy data yields exceptions from established rules of outer retinal connectivity.
    1. Neuroscience

    Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers

    Timothy S Balmer, Laurence O Trussell
    Distinct inputs to the cerebellum make contact on specific subtypes of target neurons.
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley et al.
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Cell Biology

    The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi

    Olga Martzoukou et al.
    In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers

    Jessica E Scholey et al.
    The Bipolar Assembly domain of kinesin-5 comprises an anti-parallel four-helix bundle, which explains how kinesin-5 subunits assemble into bipolar tetramers with two motile ends that transmit forces while crosslinking and sliding adjacent microtubules during mitosis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes

    Daniel B Cortes et al.
    Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski et al.
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Neuroscience

    Dipolar extracellular potentials generated by axonal projections

    Thomas McColgan et al.
    Action potentials propagating in axon bundles with bifurcating and terminating fibers cause strong and far-reaching extracellular potentials.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties

    Luca Melli et al.
    Individual nonmuscle myosin 2 filaments in cells may differ their mechanical and kinetic properties depending on the myosin paralog composition giving the cells a mechanism for fine tuning the output of a given nonmuscle myosin filament.
    1. Cell Biology

    Functional dichotomy and distinct nanoscale assemblies of a cell cycle-controlled bipolar zinc-finger regulator

    Johann Mignolet et al.
    Forward genetics and super-resolution microscopy identifies ZitP as a conserved multifunctional regulator that accumulates at both cell extremities in distinct macromolecular structures to perform different functions in the asymmetric model bacterium Caulobacter crescentus.

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