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    1. Cell Biology
    2. Developmental Biology

    Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division

    Felipe Mora-Bermúdez et al.
    Mammalian neural stem cells specifically regulate a subset of astral microtubules to govern the subtle changes in spindle orientation that underlie symmetric vs asymmetric cell division during embryonic cortical neurogenesis.
    1. Neuroscience

    Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision

    Silvia JH Park et al.
    Anatomical and physiological analyses identified an inhibitory interneuron that is an integral part of the rod bipolar cell pathway, the circuit for night vision, of the mammalian retina.
    1. Developmental Biology

    N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

    Elif Kon et al.
    FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui et al.
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Neuroscience

    Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior

    Ignacio Sarria et al.
    Adjusting key parameters of the synaptic transmission at a single defined synapse of the visual circuit can affect properties of this circuit and animal behavior.
    1. Neuroscience

    Cross-synaptic synchrony and transmission of signal and noise across the mouse retina

    William N Grimes et al.
    Cells within the retina synchronize transmitter release across their output synapses in the dark, reducing the impact of noise generated at these synapses and allowing light-dependent signals to be transmitted with minimal added synaptic noise.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Computational and Systems Biology
    2. Plant Biology

    Rapid transporter regulation prevents substrate flow traffic jams in boron transport

    Naoyuki Sotta et al.
    To avoid internal traffic jams of nutrients that they absorb, plants need to swiftly regulate the transporters that take up those nutrients.
    1. Microbiology and Infectious Disease

    Global phenotypic profiling identifies a conserved actinobacterial cofactor for a bifunctional PBP-type cell wall synthase

    Joel W Sher et al.
    A broadly useful phenotypic profiling dataset was generated and used to identify a cofactor required for a polar cell wall synthase in Corynebacterium glutamicum that is conserved throughout the Actinobacteria.
    1. Microbiology and Infectious Disease

    The alternative sigma factor σX mediates competence shut-off at the cell pole in Streptococcus pneumoniae

    Calum HG Johnston et al.
    Tracking fluorescent fusion proteins in competent pneumococcal cells reveals a polar hub for competence regulation, with the alternative sigma factor σX relocalizing DprA to this hub to mediate competence shut-off.