25 results found
    1. Stem Cells and Regenerative Medicine

    Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    Simon Perrin, Maria Ethel ... Céline Colnot
    A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
    1. Stem Cells and Regenerative Medicine

    Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis

    Corentin Bernou, Marc-André Mouthon ... François Dominique Boussin
    Characterization of an abundant clonogenic and multipotent population of immature neuroblasts, at the transition between transient-amplifying progenitor (TAP) neuroblasts and migratory neuroblasts, reversibly engaged in neuronal differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

    Joseph A Bisson, Miriam Gordillo ... Todd Evans
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Human myogenic progenitor cells display tenogenic differentiation potential and facilitate tendon regeneration

    Xiexiang Shao, Xingzuan Lin ... Ping Hu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

    Yifan Wu, Kunhua Qin ... Pei Wang
    Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Endothelial cell signature in muscle stem cells validated by VEGFA-FLT1-AKT1 axis promoting survival of muscle stem cell

    Mayank Verma, Yoko Asakura ... Atsushi Asakura
    Bulk and single-cell RNA-seq data demonstrated that muscle stem cells express low levels of canonical endothelial cell markers, including VEGFA receptors, and VEGFA-FLT1 pathway has a drastic effect on muscle stem cell survival through AKT1 in vitro and in vivo.
    1. Developmental Biology

    Conditional blastocyst complementation of a defective Foxa2 lineage efficiently promotes the generation of the whole lung

    Akihiro Miura, Hemanta Sarmah ... Munemasa Mori
    The Foxa2 lineage-based organ generative strategy allows us to establish a unique paradigm for the simultaneous generation of functional whole lungs and thymus, which can be applied to future transplantation therapy.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Developmental Biology

    Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

    Pankaj Sahai-Hernandez, Claire Pouget ... David Traver
    A rare population of endothelial cells emerges from a bipotent muscle progenitor population in the paraxial mesoderm and provides niche support to induce hematopoietic stem cells.
    1. Cancer Biology

    Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

    Jiangfei Chen, Kunal Baxi ... Myron S Ignatius
    Zebrafish are an optimal model organism to study rare TP53 mutations whose functions are not readily understood.

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