205 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex

    Sarah K Bowman et al.
    Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.
    1. Developmental Biology

    The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6

    Yun Qing et al.
    Elucidating the molecular mechanism by which the Hippo signaling effector Yorkie (Yki) functions as a transcriptional coactivator in growth control reveals the importance of a histone-modifying enzyme for this process.
    1. Stem Cells and Regenerative Medicine

    Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor Buttonhead

    Hideyuki Komori et al.
    The Drosophila equivalent of the human protein Mixed Lineage Leukemia 1n enables neural stem cells to generate neural progenitors through the fly equivalent of the human transcription factor Sp8, thereby contributing to an increased number and diversity of cell types during brain development.
    1. Neuroscience

    A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila

    Andrew M Seeds et al.
    Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Kelvin Yeung et al.
    ChIP-seq and phenotypic analyses reveal Atrophin from Drosophila directly regulates Notch and Dpp signaling components, and engrailed gene expression, via interactions with GAGA Factor.
    1. Developmental Biology

    Neuron hemilineages provide the functional ground plan for the Drosophila ventral nervous system

    Robin M Harris et al.
    Hemilineages link neuronal stem cells to behavioral functions by providing a conserved ground plan of neuronal types that evolution then uses to sculpt different types of walking and flight behaviors.
    1. Structural Biology and Molecular Biophysics

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.
    1. Developmental Biology

    Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners

    Ke Li, Nicholas E Baker
    Developmental genetic and cell culture studies indicate that the Inhibitor of DNA-binding protein Extra macrochaetae (Emc), previously thought to determine where bHLH proteins can act, is itself regulated by those bHLH dimerization partners at the level of protein stability.
    1. Neuroscience

    The roles of vision and antennal mechanoreception in hawkmoth flight control

    Ajinkya Dahake et al.
    Mechanosensors in the antennae of hawkmoths provide rapid sensory feedback for the control of fast flight manoeuvres, which acts in parallel to visual information.
    1. Structural Biology and Molecular Biophysics

    Structural insights into SETD3-mediated histidine methylation on β-actin

    Qiong Guo et al.
    Structural research, supplemented by biochemical experiments and enzymatic assays, unravels the sequence-dependent molecular mechanism by which SETD3 recognizes β-actin and methylates His73 of β-actin.

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