Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.

Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.

A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.

Boundary:boundary pairing interactions drive TAD formation in Drosophila.

A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.

CRISPR knock-outs and functional genomic approaches probe the regulatory mechanism restricting the Hox gene Ubx to butterfly hindwings, explaining color pattern differentiation from forewings.

Tucked within a well-known story of diverging gene function is a single enhancer encoding two inseparable specificities that regulates two adjacent genes, each with different spatiotemporal expression patterns.

The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.

Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.