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A regulatory circuit that localizes to the synaptonemal complex, a liquid crystalline compartment between chromosomes, ensures crossing-over while limiting the number of crossovers between homologous chromosomes during meiosis.

A comprehensive resource based on analysis of the responses of embryonic ectoderm cells to signals from the 'organizer' (the node) including transcriptional responses and epigenetic changes with fine temporal dynamics, predicted regulatory interactions, and conservation among vertebrates.

ARID1A is implicated in BAF-A-governed meiotic sex chromosome gene regulation and sex-linked chromatin dynamics in DNA repair.

Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.

Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.

A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.

The design and validation of an oligo-based DNA FISH library that targets the entire Caenorhabditis elegans genome at chromosome, three megabase, and 500 kb scales.

Investigation of meiosis in the nematode Pristionchus pacificus has illuminated evolutionary variation in this essential aspect of reproduction and established a new model for future study.

Potent and low-cost Nanosota-1 drug candidates block SARS-CoV-2 infections in vitro and in animal models and act preventively and therapeutically.

A domain in the ORF1 polyprotein of the hepatitis E virus that was previously thought to be a protease is actually a zinc-binding domain.