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    1. Immunology and Inflammation
    2. Medicine

    JAK inhibition decreases the autoimmune burden in Down syndrome

    Angela L Rachubinski, Elizabeth Wallace ... Joaquín M Espinosa
    Treatment with a JAK inhibitor normalizes multiple biomarkers of autoinflammation and provides therapeutic benefit for diverse immune skin conditions in individuals with Down syndrome.
    1. Neuroscience

    Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty

    Gaqi Tu, Peiying Wen ... Kaori Takehara-Nishiuchi
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Three-dimensional single-cell transcriptome imaging of thick tissues

    Rongxin Fang, Aaron Halpern ... Xiaowei Zhuang
    By integrating multiplexed error-robust fluorescence in situ hybridization (MERFISH), deep learning, optical sectioning, and protocol optimization, thick-tissue 3D MERFISH allows volumetric single-cell transcriptome imaging of thick-tissue samples, broadening the scope of applications of spatial genomics.
    1. Cell Biology
    2. Neuroscience

    Projection neurons are necessary for the maintenance of the mouse olfactory circuit

    Luis Sánchez-Guardado, Peyman Razavi ... Carlos Lois
    Ablation of olfactory projection neurons in adult mice triggers sprouting of the apical dendrite of remaining neurons towards multiple nearby glomeruli and disrupts the odor map.
    1. Medicine

    Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

    Sami Fawaz, Severine Marti ... Thierry Couffinhal
    If CHIP and mLOY do not significantly contribute to inflammation, atherosclerosis or myocardial infarction risk independently, CHIP may increase the risk of MI in men who do not carry mLOY.
    1. Neuroscience

    Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

    Yiting Li, Wenqu Yin ... Baoming Li
    Time-related sequential activities in prefrontal cortex exhibit stable coding over weeks, while representations of other variables are dynamic, suggesting that neural sequences are consisted of unique group of neurons.
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

    Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Ecology

    Integrating microscopy and transcriptomics from individual uncultured eukaryotic plankton

    Catherine Gatt, Yike Xie ... Fabio Zanini
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Evolutionary Biology

    Still waters run deep: Large scale genome rearrangements in the evolution of morphologically conservative Polyplacophora

    Julia D Sigwart, Yunlong Li ... Jin Sun
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling