580 results found
    1. Cancer Biology

    Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation

    Angela M Halstead et al.
    Bladder-cancer-associated RXRA mutations were found to stimulate urothelial proliferation through a mechanism susceptible to small molecule inhibitors of Peroxisome Proliferator-Activated Receptors, credentialing a new class of targetable drivers of bladder cancer.
    1. Neuroscience

    Brainstem network dynamics underlying the encoding of bladder information

    Anitha Manohar et al.
    Neural and network activity within a pontine-cortical micturition circuit are finely coordinated with urodynamics to assure appropriate voiding behaviors.
    1. Developmental Biology and Stem Cells

    Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

    Rachel Lander, Christian P Petersen
    Signaling molecules expressed in overlapping body-wide transcriptional gradients determine central axis positional identity in whole-body regeneration.
    1. Cell Biology

    Flagellar Growth: Boarder control on the IFT train

    Cécile Fort, Philippe Bastin
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    1. Neuroscience

    Urodynamics: How the brain controls urination

    Anna P Malykhina
    Coordination between the brainstem and the cortex helps to ensure that urination occurs at an appropriate time.
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    1. Plant Biology

    BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance

    Bo Zhang et al.
    The abundance of the PIF4 transcription factor, central in light and temperature signaling, is controlled by an E3 ligase encoded by BOP proteins.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.

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