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A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.

DUX4 expression is a common feature of metastatic tumors, where it is significantly associated with immune cell exclusion, decreased objective response to immune checkpoint blockade, and reduced patient survival.

Disrupting synapse formation between the retina and the brain in zebrafish larvae-by eliminating the molecular motor Kif5A-triggers a compensatory increase in the branching of retinal axons aimed at restoring synapse number.

A time-gated model is proposed to reconcile the transient vs. persistent biological activities of cellular senescence, in which 'time' seems to be the main orchestrator of the beneficial vs. detrimental effects of the senescent programme.

Sulforaphane through NRF2-dependent and -independent cellular and molecular pathways alleviates leptin resistance to reverse the diet-induced obesity.

Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.

Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.

Computational modeling based on experimental data reveals how spinal sensorimotor circuits control cycle and phase durations during treadmill locomotion after an incomplete spinal cord injury.