7,526 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density

    Ellie Sherrard-Smith et al.
    Combining pre-erythrocytic and transmission blocking antibodies enhances the overall control and potential elimination of malaria within both mosquito and vertebrate populations.
    1. Cell Biology

    Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

    Xun X Bao et al.
    Microtubule nucleation from the nuclear envelope in fission yeast involves repurposing of nuclear export proteins for a non-export-related function, docking cytoplasmic proteins at nuclear pore complexes.
    1. Neuroscience

    Lateral orbitofrontal neurons acquire responses to upshifted, downshifted, or blocked cues during unblocking

    Nina Lopatina et al.
    Building on previous work (McDannald et. al, 2014), it is shown that dissociable populations of neurons in the lateral orbitofrontal cortex acquire responses to cues that predict more, less, or no change in reward in rats during training in a Pavlovian unblocking task.
    1. Cell Biology
    2. Developmental Biology

    Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

    Katarzyna Nowak et al.
    Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.
    1. Neuroscience

    Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking

    Michael A McDannald et al.
    Orbitofrontal cortex neurons fire in response to cues with no value independent of what can be inferred through features of the predicted outcome.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

    Matthias Lübbert et al.
    A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.
    1. Cell Biology
    2. Developmental Biology

    Flattop regulates basal body docking and positioning in mono- and multiciliated cells

    Moritz Gegg et al.
    In cell types that acquire planar cell polarity, the protein Flattop regulates basal body docking and positioning.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro

    Tobias Brandt et al.
    A combination of an in vitro mitochondrial fusion assay with electron cryo-tomography (cryo-ET) reveals distinct steps and protein complexes during mitofusin-dependent fusion between adjacent mitochondrial outer membranes.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

    Anirban Banerjee et al.
    Charybdotoxin, a toxin produced by scorpions, blocks a K+ channel by binding in a lock-and-key fashion to the mouth of the channel and presenting a lysine amino group, which serves as a K+ mimic in the selectivity filter.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Lis1 regulates dynein by sterically blocking its mechanochemical cycle

    Katerina Toropova et al.
    Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.

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