4,847 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Imaging single-cell blood flow in the smallest to largest vessels in the living retina

    Aby Joseph, Andres Guevara-Torres, Jesse Schallek
    By using a specialized camera that corrects for eye blur, millions of single-blood-cells are imaged, and their speed measured, as they travel through the largest-to-smallest vessels of the retina.
    1. Medicine
    2. Physics of Living Systems

    Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

    Dmitry Postnov, Donald J Marsh ... Olga Sosnovtseva
    High-resolution blood flow imaging confirms the presence of large, long-living synchronous clusters in renal microcirculation and reveals how vasoactive drugs affect synchronization properties.
    1. Neuroscience

    Infant brain regional cerebral blood flow increases supporting emergence of the default-mode network

    Qinlin Yu, Minhui Ouyang ... Hao Huang
    Unprecedented 4D spatiotemporal infant regional cerebral blood flow framework and region-specific physiology–function coupling across infancy were elucidated, highlighting strong physiology–function coupling specifically at the default-mode network to meet extraneuronal metabolic demand for network emergence.
    1. Cell Biology
    2. Physics of Living Systems

    Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

    Steffen M Recktenwald, Greta Simionato ... Stephan Quint
    For severe COVID-19 patients' red blood cells, healthy donor plasma reduces pathological red blood cell shape alterations and improves microcapillary flow in vitro through an interaction between red blood cells and plasma.
    1. Neuroscience

    The severity of microstrokes depends on local vascular topology and baseline perfusion

    Franca Schmid, Giulia Conti ... Bruno Weber
    The number of inflows and outflows at the occluded capillary governs the local flow reduction, and the different topological configurations are probably designed for distinct functional tasks.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation

    Charles E MacKay, Miranda Floen ... Jonathan H Jaggar
    Flow stimulates PC-1/PC-2 clusters in the plasma membrane of endothelial cells, leading to Ca2+ influx, NOS, SK channel, and IK channel activation, vasodilation, and a reduction in blood pressure.
    1. Structural Biology and Molecular Biophysics

    Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

    Charles E MacKay, M Dennis Leo ... Jonathan H Jaggar
    PKD2 (polycystin-2) channels are a major component of a flow-sensing signaling mechanism in endothelial cells that stimulates vasodilation and reduces blood pressure.
    1. Cell Biology

    Intelligent classification of platelet aggregates by agonist type

    Yuqi Zhou, Atsushi Yasumoto ... Keisuke Goda
    An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.
    1. Neuroscience

    Mapping oxygen concentration in the awake mouse brain

    Declan G Lyons, Alexandre Parpaleix ... Serge Charpak
    Two-photon phosphorescence lifetime microscopy reveals the physiological values of oxygen concentration and blood flow parameters in the brains of awake mice.
    1. Neuroscience

    In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

    Morgane Roche, Emmanuelle Chaigneau ... Serge Charpak
    Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.

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