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Under metabolic syndrome, joint subchondral preosteoclasts acquire a senescence-associated secretome, which causes a rapid structural alteration of subchondral bone and contributes to the development of osteoarthritis.

In the tumor microenvironment, only specific subsets of cytotoxic and immunosuppressive tumor-infiltrating lymphocytes are endowed with active translation.

Lineage-specific Drosophila cell lines provide in vitro models for cell, biochemical, and high-throughput analyses in defined cell types.

Inhibition of S100a4 represents a novel anti-fibrotic target to improve tendon healing.

Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.

Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.

The gut microbiota of East Asians is distinct, dissociated from body mass, and self-sustains compared to White subjects from the same region, and therein may underpin a key health disparity.

Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.

The placement of single methyl groups at certain positions in the sequence of small model transmembrane proteins consisting solely of leucines and isoleucines can modulate highly specific, productive interactions with the transmembrane domain of the erythropoietin receptor.

Mechanistic insight into the role of intranuclear Nup98 in gene expression is revealed by functional interactions with the helicase DHX9.