Paul Knabl, Alexandra Schauer ... Grigory Genikhovich
ChIP-seq analysis reveals BMP signaling targets in a cnidarian and identifies ZSWIM4-6 as a dampener of the pSMAD1/5 gradient and a potential conveyor of the BMP-mediated gene repression.
The non-signaling complex formed by Activin A and ACVR1 is operant in vivo and is required to temper the degree of heterotopic ossification in the genetic disorder fibrodysplasia ossificans progressiva.
Alec K Gramann, Arvind M Venkatesan ... Craig J Ceol
The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.
Luyang Xiong, Irina Zhevlakova ... Tatiana V Byzova
Cell and animal-based models revealed the new function of TLR2 andcarboxyethylpyrrole as an endogenous TLR2 ligand in the hair follicle cycle in homeostasis and hair follicle regeneration in injury.
Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
Fate-mapping, combined with gain- and loss-of-function approaches, reveal the role of BMP signalling in the spatio-temporal development of the tuberal hypothalamus, a critically important brain region.