4,618 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system

    Joseph Crispell et al.
    Analyses combining genomic and epidemiological data of Mycobacterium bovis, which causes bovine tuberculosis, revealed evidence of transmission within and between cattle and badger populations.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao et al.
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Context-dependent deposition and regulation of mRNAs in P-bodies

    Congwei Wang et al.
    An unbiased screen using various stresses reveals selective mRNA transport into P-bodies, in which mRNAs are either stored or decayed in a process that may promote chronological lifespan in yeast.
    1. Neuroscience

    Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

    Mengchen Ye et al.
    Multivesicular bodies deliver long-range retrograde nerve growth factor (NGF) signals and serve as essential signaling and sorting platforms in the cell soma, and multivesicular body (MVB) cargoes dictate their vesicular fate.
    1. Chromosomes and Gene Expression

    Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

    Jacob M Vogan et al.
    The Cajal body chaperone TCAB1 and scaffold protein Coilin are not required for telomerase activity in human cells.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

    James E Hughes Hallett et al.
    The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

    Jeffrey T Lock, Ian Parker
    Cell-wide Ca2+ signals that regulate numerous cellular functions comprise dual Ca2+ release modes through IP3 receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.
    1. Neuroscience

    The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

    Veronique Amor et al.
    Single and double-knockout mouse models for proteins associated with nodes of Ranvier reveal that a paranodal, spectrin-based lateral diffusion barrier is sufficient to cluster Na+ channels at nodes of Ranvier.
    1. Cell Biology
    2. Computational and Systems Biology

    An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

    Hamdah Shafqat-Abbasi et al.
    “Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

    Lotte P Watts et al.
    The RIF1-long and short splice variants show distinct ability to protect cells from replication stress by promoting 53BP1 nuclear bodies, representing the first described functional difference between the two variants.

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