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An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.

Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.

The p.Arg707Trp mutation in Mfn2 causes adipose-specific activation of the integrated stress response, which lowers secretion of adipokines.

Mitochondrial fission, associated with fatty acids oxidation, is fundamental for AgRP neuronal activity during negative energy balance and in regulating fasting- and/or ghrelin-induced feeding.

A hormone released after mating acts directly on adult intestinal progenitors and differentiated epithelial cells in Drosophila to change their homeostatic setpoint and maximise fecundity.

Leveraging time-varying and tissue-dependent genetic instruments into Mendelian randomization studies may help develop insight over more conventional applications.

miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.

Immune activation in Drosophila macrophages during oxidative stress is regulated by DNA damage signaling, which controls proinflammatory cytokine release and the susceptibility of the fly to oxidative stress.

The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.

Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.