11,103 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

    Ilhame Diboun et al.
    PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.
    1. Medicine

    The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

    Melanie Castro-Mollo et al.
    The hepcidin regulator erythroferrone functions by sequestering BMPs and is an important modulator of bone remodeling, providing new mechanistic insight into how premature osteoporosis persists in optimally transfused β-thalassemic patients.
    1. Cell Biology

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
    1. Medicine

    Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

    Marlies P Noz et al.
    In patients with coronary artery disease, bone marrow myeloid progenitor cells are reprogrammed towards myeloid skewing and inflammatory activation.
    1. Biochemistry and Chemical Biology

    Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

    Peter Ahorukomeye et al.
    The unique modus operandi of cone snail venom insulins provides new insight into insulin receptor activation and informs on the design of insulin analogs for the treatment of diabetes.
    1. Cell Biology

    The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

    Yaron Vinik et al.
    The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.
    1. Cancer Biology
    2. Cell Biology

    Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

    Qi Deng et al.
    Cartilage and bone tumors arise from chondrocyte or osteoblast progenitors but not differentiated cells or multipotent mesenchymal stem cells (MSCs) via the IHH-Wnt/β-Catenin pathway.
    1. Medicine

    Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

    Qi Sun et al.
    Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.
    1. Neuroscience

    Human foveal cone photoreceptor topography and its dependence on eye length

    Yiyi Wang et al.
    Despite evidence of retinal stretching with eye growth, cone photoreceptor sampling density in the foveal center of humans actually increases with eye length.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu et al.
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.

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