1,032 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Microstructural differences in the osteochondral unit of terrestrial and aquatic mammals

    Irina AD Mancini, Riccardo Levato ... Jos Malda
    Analysis of the osteochondral unit of aquatic mammals reveals a distinctly different tissue structure, lacking the arcade-like collagen fiber organization, a calcified cartilage layer and a dense subchondral bone plate, typically seen in osteochondral tissue of terrestrial mammals.
    1. Cell Biology

    MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

    Ellen Phillips, Naseer Ahmad ... Deborah L Johnson
    Identification of a novel role for the transcriptional repressor, MAF1, and RNA polymerase III-dependent transcription, in osteoblast differentiation, mineralization, and bone biology.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities

    Evan T Saitta, Renxing Liang ... Tullis Onstott
    Subterranean fossil bone hosts a living microbiome different from the surrounding sediment without evidence of original protein preservation.
    1. Evolutionary Biology

    Preliminary paleohistological observations of the StW 573 (‘Little Foot’) skull

    Amélie Beaudet, Robert C Atwood ... Dominic Stratford
    Virtual investigation of the 3.67-million-year-old skull of 'Little Foot' using synchrotron radiation reveals histological details of Australopithecus dental and bone tissues.
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.
    1. Ecology

    Oxygen isotopes suggest elevated thermometabolism within multiple Permo-Triassic therapsid clades

    Kévin Rey, Romain Amiot ... Christophe Lécuyer
    Two therapsid clades, dicynodonts and cynodonts, independently acquired and developed an endotherm-like thermoregulation during the Late Permian period, that probably helped them to survive the major global climate and environmental fluctuations of the end-Permian.
    1. Cell Biology
    2. Immunology and Inflammation

    Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1

    Maria-Bernadette Madel, Lidia Ibáñez ... Claudine Blin-Wakkach
    Osteoclasts emerging in inflammation are heterogeneous and encompass a strongly inflammatory subset with a high resorbing activity and an immune suppressive subset that are able to control each other.
    1. Stem Cells and Regenerative Medicine

    Distinct skeletal stem cell types orchestrate long bone skeletogenesis

    Thomas H Ambrosi, Rahul Sinha ... Charles KF Chan
    Functional and molecular analyses of two distinct skeletal stem cell populations establish the important role of stem cell diversity that provides a framework for novel investigations into skeletal biology.
    1. Cancer Biology

    Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim, Amirali Afshari ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Productivity loss associated with functional disability in a contemporary small-scale subsistence population

    Jonathan Stieglitz, Paul L Hooper ... Michael D Gurven
    Adult spinal fracture substantially impairs subsistence productivity, particularly for men.

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