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    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Neuroscience

    Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning

    Yan Yang, Stephen G Lisberger
    During learning, one climbing fiber input instructs plasticity that is expressed in the simple-spike responses of cerebellar Purkinje cells, and causes neural learning that may inhibit future climbing fiber instructions.
    1. Neuroscience

    Cognitive regulation alters social and dietary choice by changing attribute representations in domain-general and domain-specific brain circuits

    Anita Tusche, Cendri A Hutcherson
    Regulatory success operates by goal-consistent increases and decreases of distinct attribute representations in generic neural hubs and in domain-specific brain regions, explaining when and why regulatory success generalizes across domains and contexts.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

    Christopher D Todd et al.
    Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.
    1. Microbiology and Infectious Disease

    MxB sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface

    Richard J Miles et al.
    Conformational flexibility in HIV-1 capsid, provided by cyclophilin A binding, facilitates evasion of capsid-targeting restriction factor MxB, while allowing sequence change to facilitate cytotoxic T-cell evasion.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Cell Biology
    2. Developmental Biology

    Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues

    Katarzyna Nowak et al.
    Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

    Jonathan M Wagner et al.
    Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina

    Jasper J Visser et al.
    An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
    1. Cell Biology
    2. Computational and Systems Biology

    Evaluation of predictions of the stochastic model of organelle production based on exact distributions

    C Jeremy Craven
    A reanalysis of the stochastic model of organelle production (Mukherji and O'Shea, 2014) suggests that this model requires significant further discussion.