9,794 results found
    1. Cell Biology

    The mechanosensitive Piezo1 channel is required for bone formation

    Weijia Sun et al.
    Piezo1 functions as a key mechanotransducer for conferring mechanosensitivity to osteoblasts and determining mechanical-load-dependent bone formation, and represents a novel therapeutic target for treating osteoporosis or unloading-induced severe bone loss.
    1. Cell Biology
    2. Developmental Biology

    Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

    Jennifer Bagwell et al.
    Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
    1. Medicine

    Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

    Cheng-Chia Tang et al.
    Simultaneous inhibition of two distinct kinase targets stimulates bone formation without concurrently increasing bone resorption, therefore representing a promising new treatment strategy for osteoporosis.
    1. Cell Biology

    Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration

    Hyo Rim Ko et al.
    Akt mediated S14 phosphorylation of Id2 augments its protein stability and growth cone localization, promoting growth cone formation and axon growth in the developing neuron and contributing to axon regeneration in the damaged hippocampus slice.
    1. Cell Biology

    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

    Nicole R Gould et al.
    Mechanical loading and the bone anabolic action of parathyroid hormone result in rapid, lysosomal degradation of sclerostin protein, revealing physiologically important post-translational control of this critical regulator of bone formation.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Computational and Systems Biology
    2. Neuroscience

    The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch

    Janine M Daum et al.
    Correlating changes in structure and gene expression in cone photoreceptors of mice daily, between birth and eye opening, created a resource that supports research in photoreceptor function, development, transplantation and repair.
    1. Developmental Biology

    Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

    Taifeng Zhou et al.
    Mechanosensitive channels Piezo1/2 are required for osteoblast differentiation from progenitors by sensing fluid sheer stress and matrix rigidity and regulating NFATc1, YAP1 and ß-catenin activities through Ca2+ stimulated phosphatase calcineurin.
    1. Cell Biology

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
    1. Structural Biology and Molecular Biophysics

    Mechanisms of ribosome stalling by SecM at multiple elongation steps

    Jun Zhang et al.
    Nascent regulatory peptides tune the translation rate through a continuous, dynamic reshaping of the functional center of the ribosome.

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