1,473 results found
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

    Krystel El Hage, Nicolas Babault ... David Pastré
    The development of an integrative computational-experimental approach for identifying small molecules that can disrupt RNA:protein interactions in vitro and in cells led to the identification of several inhibitors of YBX1 in the micromolar range, including a previously approved drug.
    1. Neuroscience

    Distinct higher-order representations of natural sounds in human and ferret auditory cortex

    Agnès Landemard, Célian Bimbard ... Yves Boubenec
    Auditory representations of natural sounds are similar in primary auditory cortex of ferrets and humans, but diverge sharply in non-primary areas for speech and music sounds.
    1. Physics of Living Systems

    Local volume concentration, packing domains, and scaling properties of chromatin

    Marcelo A Carignano, Martin Kroeger ... Igal Szleifer
    The Self Returning Excluded Volume model is the first heuristic, stochastic chromatin model that reproduce single cell and ensemble based experiments bridging nucleosome and chromosome scales.
    1. Neuroscience

    Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

    Evan D Vickers, David A McCormick
    Procedures were developed to perform mesoscale 2-photon Ca2+ imaging simultaneously from all of mouse dorsolateral neocortex, facilitating identification of widespread neural ensembles with activity related to diverse aspects of behavior.
    1. Neuroscience

    Distinct neural contributions to metacognition for detecting, but not discriminating visual stimuli

    Matan Mazor, Karl J Friston, Stephen M Fleming
    Combining psychophysics and functional MRI reveals a qualitative asymmetry in neural engagement when reflecting on whether a stimulus is seen (detection) compared to reflecting on what a stimulus is (discrimination).
    1. Ecology
    2. Evolutionary Biology

    Comparative genomics explains the evolutionary success of reef-forming corals

    Debashish Bhattacharya, Shobhit Agrawal ... Paul G Falkowski
    The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.
    1. Neuroscience

    Inferring control objectives in a virtual balancing task in humans and monkeys

    Mohsen Sadeghi, Reza Sharif Razavian ... Dagmar Sternad
    A virtual balancing task with parallel experiments on human and non-human primates revealed a spectrum of behaviors (classified by a computational model into position, velocity, or mixed control strategy) that can serve as basis for analyzing neural population dynamics.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Protein sequences bound to mineral surfaces persist into deep time

    Beatrice Demarchi, Shaun Hall ... Matthew J Collins
    A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.
    1. Neuroscience

    Early parafoveal semantic integration in natural reading

    Yali Pan, Steven Frisson ... Ole Jensen
    During natural reading, before we fixate on a word, we can already extract its meaning and even integrate it into the evolving context.

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