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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    2-oxoglutarate triggers assembly of active dodecameric Methanosarcina mazei glutamine synthetase

    Eva Herdering, Tristan Reif-Trauttmansdorff ... Ruth A Schmitz
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Newly discovered and conserved role of IgM against viral infection in an early vertebrate

    Weiguang Kong, Xinyou Wang ... Zhen Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Physics of Living Systems

    Stability vs flexibility: reshaping archaeal membranes in silico

    Miguel Amaral, Felix Frey ... Anđela Šarić
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss

    Lorenzo Ghezzi, Ulrike Pech ... Patrik Verstreken
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

    Chengfang Pan, Ying Liu ... Changlong Hu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells promote cytotoxic CD8 T cell activation

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Statistical learning beyond words in human neonates

    Ana Fló, Lucas Benjamin ... Ghislaine Dehaene-Lambertz
    Human neonates process regularities in speech's phonetic and voice content in parallel, but only phonetic regularities evoke a specific ERP component in a post-learning phase.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

    Ashley L Cook, Surojit Sur ... Nicolas Wyhs
    Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Protection afforded by post-infection SARS-CoV-2 vaccine doses: A cohort study in Shanghai

    Bo Zheng, Bronner P Gonçalves ... Caoyi Xue
    The observation that an additional vaccine dose provides protection against Omicron variant reinfection in previously vaccinated and infected individuals will help guide future COVID-19 vaccination policies in China and globally.
    1. Cell Biology
    2. Physics of Living Systems

    De novo identification of universal cell mechanics gene signatures

    Marta Urbanska, Yan Ge ... Jochen Guck
    A computational systems biology approach identifies a gene network module associated with single-cell mechanical phenotype changes across diverse mouse and human systems, with implications for on-demand engineering of cell stiffness.