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    1. Neuroscience

    Vocalization categorization behavior explained by a feature-based auditory categorization model

    Manaswini Kar, Marianny Pernia ... Srivatsun Sadagopan
    A theoretical model that uses maximally informative spectrotemporal features to classify vocalizations, trained solely on natural guinea pig vocalizations, predicts guinea pig behavioral performance in classifying natural as well as spectrotemporally manipulated vocalizations.
    1. Physics of Living Systems

    Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

    Cecilia Lövkvist, Pawel Mikulski ... Martin Howard
    Extra protein memory storage elements with positive feedbacks, in addition to histone modifications, can explain epigenetic switching and memory at the PRC2 target gene FLOWERING LOCUS C (FLC).
    1. Developmental Biology
    2. Genetics and Genomics

    Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

    Morgan Thompson, Ryan Bixby ... Adam D Norris
    Single-cell splicing of a conserved neuronal kinase is established by a combinatorial code of fate-determining transcription factors and neuronal RNA binding proteins, with different combinations in different neuron types.
    1. Neuroscience

    Opioids modulate an emergent rhythmogenic process to depress breathing

    Xiaolu Sun, Carolina Thörn Pérez ... Kaiwen Kam
    Inspiratory rhythmogenesis is mediated by an emergent mechanism independent of bursts associated with motor output and is modulated by opioids, pointing to strategies for ameliorating opioid-induced respiratory depression.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor

    Harriet Lane-Serff, Paula MacGregor ... Mark Carrington
    The ligand specificity and expression profile of the haptoglobin-haemoglobin receptor has diversified throughout the evolution of trypanosomes.
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt, Shristi Pandey ... Xiaowei Zhuang
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Immunology and Inflammation

    Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells

    Małgorzata Anna Cichoń, Karin Pfisterer ... Adelheid Elbe-Bürger
    Reticulon 1A plays a central role not only in cytoskeletal remodeling of resident Langerhans cells but also in their clustering upon Toll-like receptor activation in human skin, suggesting an important role in maintaining tissue homeostasis.
    1. Developmental Biology

    Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

    Swati Sharma, Richa Rikhy
    The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.
    1. Evolutionary Biology

    Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

    Taro Maeda, Shunichi Takahashi ... Shuji Shigenobu
    The newly opened genome of a kleptoplastic mollusk, Plakobranchus ocellatus, indicated that sequestered plastids retain their activity within the animal cell without horizontal algal gene transfer to the animal nucleus.
    1. Cell Biology

    Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas

    Shufen Li, Kirsty Y Wan ... Junmin Pan
    Experimental and modelling analyses suggest a non-linear scaling relationship between IFT velocity and ciliary length that can be accounted for by limitation of the motors.