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Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in
Karine Narbonne-Reveau et al.
Sequentially expressed temporal transcription factors in neural stem cells during early development determine which progeny can undergo malignant transformation upon dedifferentiation.
Meta-Research: Tracking the popularity and outcomes of all bioRxiv preprints
Richard J Abdill, Ran Blekhman
Data are reported for the monthly number of uploads to and downloads from bioRxiv, and for the number of preprints that are later published in peer-reviewed journals.
Meta-Research: Gender variations in citation distributions in medicine are very small and due to self-citation and journal prestige
Jens Peter Andersen et al.
In studies of gender disparities in academia, increased focus is required on within-group variability and between-group overlap of distributions when interpreting and reporting results.
Microbiology and Infectious Disease
Defining the function of OmpA in the Rcs stress response
Kilian Dekoninck et al.
In vivo and in vitro approaches uncover a new function for the β-barrel OmpA and reveal how it interacts with the stress sensor lipoprotein RcsF.
Antagonistic control of
germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2
Xiaobo Wang et al.
Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
Impaired adaptation of learning to contingency volatility in internalizing psychopathology
Christopher Gagne et al.
Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
Genetics and Genomics
Alternative polyadenylation mediates genetic regulation of gene expression
Briana E Mittleman et al.
Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.
Genetics and Genomics
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages
Lauren M Saunders et al.
Single-cell transcriptomics combined with genetic analyses identify post-embryonic neural crest subpopulations and thyroid hormone dependencies in zebrafish adult pigment pattern development.
Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome
Irene Bolea et al.
Glutamatergic brainstem neurons drive motor and respiratory deficits, and GABAergic basal ganglia neurons cause hypothermia and fatal epileptic events, in a model of mitochondrial disease.
Computational and Systems Biology
Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases
Rahil Taujale et al.
Deep mining of GT-A fold sequences provides an evolutionary framework for investigating complex relationships connecting GT-A fold sequence, structure, function and regulation.
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