Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
Empirical evidence suggests that the hippocampus constructs maps of spatial environments based on the relative locations of places (i.e., topology), rather than absolute distances and coordinates (i.e., geometry).
Chromatin remodeler Hmga1 has two separable functions in neural crest development, first neural crest specification at the neural plate border and later in Wnt-dependent emigration from the neural tube.
Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant mutant virus indicating potential clinical benefits for combining these two classes of inhibitors.