For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
Matthew T Parker, Katarzyna Knop ... Gordon G Simpson
Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
Gabriela C Olivera, Emily C Ross ... Antonio Barragan
The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
Thomas Grandits, Christoph M Augustin ... Alexander Jung
Neural networks can emulate normal and abnormal human ventricular action potentials accurately and potentially much faster than regular simulations paving the way for more efficient quantitative systems pharmacology studies.
A computational framework and analysis of rodent CA1 data reveals that theta oscillations sequentially sweep through the past, present, and future at a spatial scale that varies with the characteristic speed of the animal.
Marco Marconi, Marcal Gallemi ... Krzysztof Wabnik
The spatial-temporal computer model of plant root meristem combines biomechanics and biochemical scales to reveal design principles underlying cell polarity and anisotropic growth during root development.
Analyses of cell type-specific data show that the maternal alleles of genes related to establishing and breaking seed dormancy are suppressed by different combinations of epigenetic marks in the endosperm of Arabidopsis.