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    1. Cancer Biology
    2. Cell Biology

    Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

    Helena Brezovjakova, Chris Tomlinson ... Vania MM Braga
    Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
    1. Developmental Biology

    scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

    Yong-Il Kim, Rebecca O'Rourke, Charles G Sagerström
    Combined single nucleus RNAseq and ATACseq enabled the first molecular resolution of all hindbrain rhombomeres, the derivation of a unique gene regulatory network for each rhombomere, and the identification of gene expression changes as rhombomeres form from early progenitor pools.
    1. Neuroscience

    Experience shapes chandelier cell function and structure in the visual cortex

    Koen Seignette, Nora Jamann ... Christiaan N Levelt
    Chandelier cells in primary visual cortex show experience-dependent plasticity, respond strongly to behaviorally relevant stimuli and only weakly inhibit pyramidal cells.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek, Julius Fürsch ... Florian Stengel
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa, Leo Otsuki ... Osvaldo Chara
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez, Franz Kuchling ... Juan R Martínez-Morales
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin-4 KIF21B is a potent microtubule pausing factor

    Wilhelmina E van Riel, Ankit Rai ... Anna Akhmanova
    Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
    1. Neuroscience

    Conditioning sharpens the spatial representation of rewarded stimuli in mouse primary visual cortex

    Pieter M Goltstein, Guido T Meijer, Cyriel MA Pennartz
    Stimulus-reward learning sharpens the local representation of the visual space while leaving the overall retinotopic map intact.
    1. Cell Biology
    2. Developmental Biology

    Pentagone internalises glypicans to fine-tune multiple signalling pathways

    Mark Norman, Robin Vuilleumier ... George Pyrowolakis
    Glypican proteins, required for morphogen signalling in Drosophila wing development, are endocytosed and degraded by the feedback regulator Pentagone.
    1. Neuroscience

    Emergence of social cluster by collective pairwise encounters in Drosophila

    Lifen Jiang, Yaxin Cheng ... Yan Zhu
    Cascades of transient pairwise interactions, stabilized by multisensory inputs, drive the formation of a well-organized social structure from a group of loosely distributed flies.