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    1. Developmental Biology
    2. Neuroscience

    Adult-born neurons modify excitatory synaptic transmission to existing neurons

    Elena W Adlaf et al.
    The formation of new neurons in the adult dentate gyrus causes a proportion of cortical neurons to transfer their existing connections to the newborn cells.
    1. Neuroscience

    Male Mating Behaviour: The importance of waiting

    Jarred Sanders, David Biron
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    1. Cell Biology

    Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

    Anna P Baron et al.
    Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

    Byron C Williams et al.
    The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Genetic Novelty: How new genes are born

    Urminder Singh, Eve Syrkin Wurtele
    Analysis of yeast, fly and human genomes suggests that sequence divergence is not the main source of orphan genes.
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    1. Ecology

    Hibernation: Life in the fast lane

    C Loren Buck
    Dormice born late in the year start to prepare for winter sooner than mice born earlier in the year.
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    1. Neuroscience

    Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain

    Yangling Mu et al.
    NMDARs promote spine formation to control survival of adult-born granule cells, but gauge spine enlargement and recruitment of AMPARs in both developing and mature neurons.
    1. Neuroscience

    Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence

    Avital Hahamy et al.
    Building on previous work (Makin et al., 2013), we show that the brains of individuals born without a hand adaptively change to compensate for their disability.
    1. Neuroscience

    Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

    Ryan J Vaden et al.
    Fast-spiking parvalbumin-expressing interneurons generate slow spillover-mediated GABAergic transmission to young adult-born and neighboring mature neurons of the dentate gyrus.
    1. Developmental Biology
    2. Neuroscience

    Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

    Ryan T Willett et al.
    The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.