243 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stochastic processes constrain the within and between host evolution of influenza virus

    John T McCrone et al.
    An analysis of influenza viruses from naturally infected people suggests a tight transmission bottleneck and little positive selection within hosts.
    1. Microbiology and Infectious Disease

    A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation

    Soo-Kyoung Kim et al.
    RNA degradation is completed through specific intermediates, such as diribonucleotides, which must be removed from the cells by a specific enzyme.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Long-term balancing selection drives evolution of immunity genes in Capsella

    Daniel Koenig et al.
    Retention of genetic diversity at immune-related loci drives the pattern of genetic variation in selfing Capsella.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

    Susanne CS Bantele et al.
    Chromatin remodelling is a key bottleneck to DNA end resection, the first and committed step of homologous recombination.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Evolutionary Biology

    Multicellularity: From brief encounters to lifelong unions

    Bradley JSC Olson
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    1. Microbiology and Infectious Disease

    Malaria: On a mission to block transmission

    Amanda Ross, Nicolas MB Brancucci
    The controlled infection of volunteers with Plasmodium falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
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    1. Microbiology and Infectious Disease

    Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

    Christine S Hopp et al.
    Malaria parasites enter the host via the skin, where they are inoculated by an infected mosquito as it probes for blood: the inoculation site is a bottleneck for the parasite and the only time when the parasite is extracellular for more than a few minutes, thus possibly presenting the best opportunity for antibody-mediated inhibition of infection.
    1. Cell Biology
    2. Genetics and Genomics

    Retrotransposons: On the move

    Sandra L Martin
    The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
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