312 results found
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu et al.
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Microbiology and Infectious Disease

    Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events

    Jun Kurushima et al.
    DNA uptake and recombination in pneumococcus are highly efficient and independent of the cell-cycle or genetic location of the transformed allele, but limited to maximally 50% of the population.
    1. Physics of Living Systems

    Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time

    William T Ireland et al.
    A combination of massively parallel reporter assays and mass spectrometry uncovers the regulation of previously unexplored promoters across the Escherichia coli genome.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A broad mutational target explains a fast rate of phenotypic evolution

    Fabrice Besnard et al.
    A broad mutational target is the cause of the high mutational variance and corresponding fast phenotypic evolutionary rate in P3.p cell fate in Caenorhabditis nematodes.
    1. Cell Biology

    Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation

    Zhao-Qian Pan et al.
    A mechanistic dissection of how autophagy kinase Atg1 is activated in fission yeast reveals surprising differences from the known Atg1 activation mechanisms previously defined in budding yeast.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Coverage-dependent bias creates the appearance of binary splicing in single cells

    Carlos F Buen Abad Najar et al.
    Sequencing and counting RNAs from single cells can create a misleading picture of alternative splicing if too many mRNAs are lost in the process.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

    Jacob A Tennessen et al.
    A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.
    1. Developmental Biology

    Building the vertebrate codex using the gene breaking protein trap library

    Noriko Ichino et al.
    The analysis of the first 1000 revertible protein trap alleles in zebrafish resulted in new functional genomic annotations and produced a panel of potential new models of human disease.
    1. Ecology
    2. Physics of Living Systems

    Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

    Amir Erez et al.
    Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants

    Carlos Martinez-Ruiz et al.
    Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.

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