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    1. Neuroscience

    Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    Moneeza A Agha, Sandeep Kishore, David L McLean
    Unexpected complexity in the synaptic basis of locomotor rhythmogenesis is linked to cell type and speed in larval zebrafish.
    1. Neuroscience

    Combining robotic training and inactivation of the healthy hemisphere restores pre-stroke motor patterns in mice

    Cristina Spalletti, Claudia Alia ... Matteo Caleo
    A combined rehabitative protocol after stroke in the mouse normalizes transcallosal inhibition and promotes "true recovery" of forelimb motor function.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen, Lei Li ... Lin Mei
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions

    Elisa Merklinger, Jan-Gero Schloetel ... Thorsten Lang
    A hierarchical model explains the self-organization of membrane microdoomaims.
    1. Cell Biology

    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

    Justin Krish Williams, Jordan Matthew Ngo ... Randy Schekman
    Plasma membrane damage causes the release of exosomes from cultured human cells.
    1. Microbiology and Infectious Disease

    Sensitizing Staphylococcus aureus to antibacterial agents by decoding and blocking the lipid flippase MprF

    Christoph J Slavetinsky, Janna N Hauser ... Andreas Peschel
    Blocking the bacterial lipid flippase MprF by monoclonal antibodies enhance staphylococcal clearance by host defense and antibiotics providing a novel proof of concept for antivirulence approaches targeting bacterial resistance mechanisms.
    1. Cell Biology
    2. Physics of Living Systems

    Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

    Camille Morel, Eline Lemerle ... Emmanuel Lemichez
    Caveolin-1 controls the width of transendothelial cell tunnels via a direct or indirect effect on membrane bending rigidity.
    1. Cell Biology
    2. Developmental Biology

    A new mode of pancreatic islet innervation revealed by live imaging in zebrafish

    Yu Hsuan Carol Yang, Koichi Kawakami, Didier YR Stainier
    A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.
    1. Neuroscience

    Intramuscular Neurotrophin-3 normalizes low threshold spinal reflexes, reduces spasms and improves mobility after bilateral corticospinal tract injury in rats

    Claudia Kathe, Thomas Haynes Hutson ... Lawrence David Falcon Moon
    Delayed intramuscular gene therapy with neurotrophin-3 after corticospinal tract injury reduces spasticity and improves locomotion by treating underlying causes of spasticity.
    1. Neuroscience

    Hypocretin underlies the evolution of sleep loss in the Mexican cavefish

    James B Jaggard, Bethany A Stahl ... Alex C Keene
    The identification of evolutionarily-derived changes in Hypocretin function within the brains of short-sleeping Mexican cavefish provides a system for investigating the mechanistic basis of sleep differences throughout the animal kingdom.