446 results found
    1. Developmental Biology

    Neural tube-associated boundary caps are a major source of mural cells in the skin

    Gaspard Gerschenfeld, Fanny Coulpier ... Piotr Topilko
    Neural tube-associated boundary caps are heterogeneous with a non-neural crest-derived subpopulation that may originate from the developing meninges, which gives rise to derivatives that migrate along nerves to detach and differentiate into skin mural cells.
    1. Cancer Biology
    2. Cell Biology

    DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

    Samantha VH Bayer, Whitney R Grither ... Gregory D Longmore
    The action of the collagen receptor DDR2 in CAFs regulates Rap1-Talin1 mediated Integrin mechanotransduction in breast tumors to impact tumor stiffness and metastases.
    1. Structural Biology and Molecular Biophysics

    Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

    James Lincoff, Cole VM Helsell ... Michael Grabe
    Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
    1. Cell Biology
    2. Computational and Systems Biology

    DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

    Xinxin Wang, Zhiming Chen ... Gaudenz Danuser
    A new user-intervention-free classification, using single-fluorescent markers, measures conventionally unmeasureable phenotypes in early stages during clathrin-mediated endocytosis.
    1. Cell Biology
    2. Physics of Living Systems

    Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material

    Medha Sharma, Tao Jiang ... Tony JC Harris
    A smooth and circular interface can form between domains of the cell cortex from local induction of a contractile actomyosin ring by centrifugal pushing forces of an expanding Arp2/3 actin network.
    1. Neuroscience

    Sensory experience modifies feature map relationships in visual cortex

    Shaun L Cloherty, Nicholas J Hughes ... Michael R Ibbotson
    A new form of brain plasticity extends the known limits for how much early sensory input can alter the brain.
    1. Cell Biology

    Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors

    Dawei Wang, Zuodong Ye ... Jianbo Yue
    CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.
    1. Physics of Living Systems

    Shape selection and mis-assembly in viral capsid formation by elastic frustration

    Carlos I Mendoza, David Reguera
    Nucleation, elasticity theory, and simulations were combined to construct a general phase diagram that elucidates the conditions for successful viral assembly and the key factors to prevent it.
    1. Medicine

    Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

    Andrea Milzi, Enrico Domenico Lemma ... Mathias Burgmaier
    Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.
    1. Neuroscience

    Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding

    Joeri BG van Wijngaarden, Susanne S Babl, Hiroshi T Ito
    An extended border coding circuit across the entorhinal and retrosplenial cortex incorporates self-referenced and viewpoint-invariant boundary information to guide navigation behavior.

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