562 results found
    1. Neuroscience

    Functional gradients of the cerebellum

    Xavier Guell et al.
    Cerebellar functional regions follow a gradual organization, which progresses from primary (motor) to transmodal (Default Mode Network) regions, and a secondary axis extends from task-unfocused to task-focused processing.
    1. Neuroscience

    Focal optogenetic suppression in macaque area MT biases direction discrimination and decision confidence, but only transiently

    Christopher R Fetsch et al.
    Perceptual decision making in monkeys can be manipulated by using optogenetics to inactivate functional subregions of visual cortex, but the brain has a capacity to compensate for this perturbation.
    1. Neuroscience

    Inferring circuit mechanisms from sparse neural recording and global perturbation in grid cells

    John Widloski et al.
    A novel experimental method and analysis is conceived, based on perturbation and sparse recording, to elucidate the circuit structure and mechanisms underlying the responses of grid cells.
    1. Neuroscience

    Characterization of developmental and molecular factors underlying release heterogeneity at Drosophila synapses

    Yulia Akbergenova et al.
    Active zone release probability is correlated with calcium channel density and calcium influx at single release sites, with release strength increasing in an activity-dependent manner during synapse maturation.
    1. Neuroscience

    Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency

    Kalina T Haas et al.
    Neuroligin 1 is a critical adhesion molecule which organizes AMPA receptor nanodomains in close vicinity to pre-synaptic release sites, and whose genetic or chemical disruption severely impairs synaptic transmission properties.
    1. Developmental Biology
    2. Neuroscience

    Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice

    Meike E van der Heijden, Huda Y Zoghbi
    Atoh1 promotes the development of two different neural circuits involved in hypoxic and hypercapnic respiratory responses that together are essential for neonatal respiratory drive and survival.
    1. Neuroscience

    Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans

    Xi Chen et al.
    Plexin controls the spatial distribution of synapses by locally inhibiting Rap2 small GTPase activity along the axon, and a Rap2 effector, TNIK, which also plays a key role in inhibiting synapse number.
    1. Neuroscience

    Content-specific activity in frontoparietal and default-mode networks during prior-guided visual perception

    Carlos González-García et al.
    Prior experience alters content-specific neural representations of visual input in frontoparietal and default-mode networks.
    1. Neuroscience

    Neurexin directs partner-specific synaptic connectivity in C. elegans

    Alison Philbrook et al.
    Investigation of synapse development using a single neuron system illuminates how individual neurons specify connectivity with their postsynaptic partners and the central role of the synaptic organizer neurexin in this process.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix et al.
    A quantitative understanding of molecular tension sensor function enables the production of unique sensors with desired mechanical properties as well as the ability to distinguish between protein force and protein deformation in mechanosensitive processes.

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