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    1. Neuroscience

    Developmental stage-specific spontaneous activity contributes to callosal axon projections

    Yuta Tezuka, Kenta M Hagihara ... Yoshiaki Tagawa
    The developing neocortex exhibits spontaneous network activity with various synchrony levels, and such activity is selectively required during a critical developmental time window for the formation of long-range axonal projections connecting the two cortical hemispheres.
    1. Developmental Biology
    2. Evolutionary Biology

    Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

    Astrid Deryckere, Ruth Styfhals ... Eve Seuntjens
    Neurogenic progenitor cells surrounding the eye placode generate neurons that migrate over long distances to the developing octopus brain.
    1. Medicine

    Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain

    Federico Salas-Lucia, Csaba Fekete ... Antonio C Bianco
    T3 is taken up by axonal termini and is retrogradely transported into endosomal vesicles to the cell nucleus, where it regulates gene expression.
    1. Cell Biology

    Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

    Kie Itoh, Daisuke Murata ... Hiromi Sesaki
    Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.
    1. Neuroscience

    Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children

    Chun Shen, Edmund T Rolls ... Jianfeng Feng
    Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

    Hourinaz Behesti, Arif Kocabas ... Mary E Hatten
    Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.
    1. Developmental Biology

    Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain

    Sweta Parab, Rachael E Quick, Ryota L Matsuoka
    Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.
    1. Medicine
    2. Neuroscience

    Multi-tract multi-symptom relationships in pediatric concussion

    Guido I Guberman, Sonja Stojanovski ... Maxime Descoteaux
    In paediatric concussions, there are a multiplicity of ways that brain damage gives rise to symptoms, most of which are missed by conventional statistical approaches and study designs.
    1. Developmental Biology
    2. Neuroscience

    Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish

    Zachary Jonas Hall, Vincent Tropepe
    Early postembryonic bodily movement sends neural feedback through dorsal root ganglia to the forebrain in order to regulate the rate of neurogenesis and subsequent brain growth.
    1. Developmental Biology
    2. Neuroscience

    Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms

    Parthiv Haldipur, Derek Dang ... Kathleen J Millen
    Building on previous work (Haldipur et al., 2014), we show that many key mechanisms controlling cerebellar development are likely conserved between mouse and human, and validate our mouse model of Dandy-Walker malformation.