2,873 results found
    1. Neuroscience

    Sleeping at the switch

    Maude Bouchard et al.
    Slow and fast switcher slow waves in human sleep show distinct EEG connectivity patterns and homeostatic regulation as well as changes during aging.
    1. Neuroscience

    Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex

    Eric Kenji Lee et al.
    WaveMAP is a novel approach that combines nonlinear dimensionality reduction with graph clustering on extracellular waveforms to reveal previously obscured cell type diversity in monkey cortex.
    1. Neuroscience

    Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

    Kate Nussenbaum, Catherine A Hartley
    The use of prior experience to adaptively prioritize information in memory increases from childhood to adulthood and engages corticostriatal circuitry.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden et al.
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson et al.
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca et al.
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

    Lloyd Davis et al.
    A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
    1. Computational and Systems Biology

    PARROT is a flexible recurrent neural network framework for analysis of large protein datasets

    Daniel Griffith, Alex S Holehouse
    PARROT makes it easy for anyone to train and use system- or data-specific deep learning models that map between protein sequence and arbitrary sequence annotations.
    1. Evolutionary Biology
    2. Physics of Living Systems

    A framework for studying behavioral evolution by reconstructing ancestral repertoires

    Damián G Hernández et al.
    The behavioral repertoires from six species of flies are measured, and a statistical approach is developed to predict co-evolving behaviors, providing a potential framework for exploring behavioral evolution.

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