Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.
An expandable cell population derived from human pluripotent stem cells exhibits properties of mesoderm and is restricted to differentiate into derivatives of intermediate mesoderm.
Amberlyn M Wands, Akiko Fujita ... Jennifer J Kohler
Cholera intoxication of human colonic epithelial cells is dependent on recognition of protein glycosylation and fucosylation, not exclusively on ganglioside recognition as proposed previously.
Felipe Mora-Bermúdez, Farhath Badsha ... Wieland B Huttner
Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
Matthew J Sternfeld, Christopher A Hinckley ... Samuel L Pfaff
Stem cell derived ventral-spinal cord excitatory neurons self-assemble into a rhythmically bursting neural network whose speed and intercellular coordination are both instructively modulated by cell-type specific interactions with inhibitory neurons.
Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
Iodixanol supplementation provides a simple method for tuning the refractive index of live imaging media, which can greatly improve resolution and penetration depth in live imaging experiments.
