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    1. Cell Biology

    A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

    Tamás Visnovitz, Dorina Lenzinger ... Edit I Buzas
    A novel 'torn bag mechanism' is described for the release of LC3 positive and negative small extracellular vesicles (exosomes) from amphiectosomes.
    Version of Record
    Short Report
    • Important
    • Compelling
    1. Neuroscience

    Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of cerebellar Purkinje cells

    Takuma Inoshita, Shin-ya Kawaguchi
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology

    A model-based factorization method for scRNA data unveils bifurcating transcriptional modules underlying cell fate determination

    Jun Ren, Ying Zhou ... Qiyuan Li
    A novel method for factorizing complex cellular trajectories into interpretable bifurcation processes enhances the understanding of cell fate determination through the identification of key biological determinants in scRNA-seq data.
    1. Neuroscience

    Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity

    Jan H Kirchner, Lucas Euler ... Julijana Gjorgjieva
    A mechanistic model based on the interaction of activity-independent cues from potential synaptic partners and local activity-dependent synaptic plasticity generates growing dendritic morphologies and non-random synaptic organization during development.
    1. Cancer Biology

    Deuterium Metabolic Imaging Phenotypes Mouse Glioblastoma Heterogeneity Through Glucose Turnover Kinetics

    Rui V Simões, Rafael N Henriques ... Noam Shemesh
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Synchronous processing of temporal information across the hippocampus, striatum, and orbitofrontal cortex

    Akihiro Shimbo, Yukiko Sekine ... Shigeyoshi Fujisawa
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology

    Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    Igor Kondrychyn, Liqun He ... Li-Kun Phng
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Immunology and Inflammation

    Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

    Weigao Zhang, Hu Liu ... Dan Weng
    Hepatocyte RIPK1 plays an important role in liver physiology, preventing liver injury and inflammation during metabolic stresses like acute fasting.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs and CD8+ T cells

    Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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