429 results found
    1. Cancer Biology
    2. Neuroscience

    Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation

    Kelda Chia et al.
    P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
    1. Cancer Biology
    2. Cell Biology

    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

    Jean M Mulcahy Levy et al.
    Pre-clinical and patient data show that inhibition of autophagy with an approved, inexpensive, well-tolerated drug can overcome resistance to BRAFV600E inhibition in multiple brain tumor subtypes with different resistance mechanisms.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

    Bo Li et al.
    The retromer complex serves as a bomb squad to retrieve and disarm the potentially harmful pool of Notch receptors in a timely manner and thereby safeguards against brain tumor formation.
    1. Developmental Biology
    2. Neuroscience

    The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors

    Yonggang Xie et al.
    The Drosophila equivalent of the human transcription factor Sp8 acts to ensure that neural progenitor cells undergo an appropriate number of cell divisions, thereby helping to regulate brain development and guard against tumor formation.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    Distinct and separable roles for EZH2 in neurogenic astroglia

    William W Hwang et al.
    A number of genes associated with the development of brain tumors are epigenetically repressed in specialized astrocytes to enable the production of neurons in the postnatal brain.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

    Lisa Landskron et al.
    Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.
    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.
    1. Cancer Biology

    Advances in Cancer Research: Authors share their research on World Cancer Day

    eLife authors discuss their latest findings in brain tumours, breast, muscle and pancreatic cancer.

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