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    1. Neuroscience

    Disordered breathing in a mouse model of Dravet syndrome

    Fu-Shan Kuo et al.
    Expression of a Dravet syndrome-associated mutation in inhibitory neurons disrupts activity of brainstem respiratory neurons and diminishes respiratory behavior in conjunction with seizures and premature death.
    1. Neuroscience

    Dynamic modulation of decision biases by brainstem arousal systems

    Jan Willem de Gee et al.
    Rapid increases in the brain’s level of alertness, or arousal, contribute to variability in decision making by reducing existing biases.
    1. Neuroscience

    Brainstem network dynamics underlying the encoding of bladder information

    Anitha Manohar et al.
    Neural and network activity within a pontine-cortical micturition circuit are finely coordinated with urodynamics to assure appropriate voiding behaviors.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips et al.
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Neuroscience

    Astrocytes release prostaglandin E2 to modify respiratory network activity

    David Forsberg et al.
    Astrocytes modulate neuronal networks during hypercapnia, introducing a novel gliotransmitter pathway where prostaglandin E2 regulates breathing.
    1. Neuroscience

    Dipolar extracellular potentials generated by axonal projections

    Thomas McColgan et al.
    Action potentials propagating in axon bundles with bifurcating and terminating fibers cause strong and far-reaching extracellular potentials.
    1. Neuroscience

    Conditioned respiratory threat in the subdivisions of the human periaqueductal gray

    Olivia K Faull et al.
    High-resolution imaging shows that the different columns of the human periaqueductal gray play differential roles in the response to a respiratory threat.
    1. Neuroscience

    Dbx1 precursor cells are a source of inspiratory XII premotoneurons

    Ann L Revill et al.
    Building on previous work (Wang et al., 2014), we use a combination of genetic, electrophysiology and laser ablation approaches to identify a developmentally defined population of neurons that are a significant source of clinically relevant inspiratory drive to XII motoneurons.