15 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer

    Iryna Kozmikova, Zbynek Kozmik
    Wnt/beta-catenin signaling is essential for the specification of dorsal cell fate in amphioxus, suggesting a common evolutionary origin for the formation of the dorsal organizer in chordates.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient origins of arthropod moulting pathway components

    André Luiz de Oliveira et al.
    Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function

    Simon Weinberger et al.
    The coding sequences of a very highly conserved family of neurogenic transcription factors from different species have evolved to generate proteins that have different life times causing them to display quantitatively different neural induction potentials.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    How lamina-associated polypeptide 1 (LAP1) activates Torsin

    Brian A Sosa et al.
    LAP1 adopts an AAA+ like fold that, while unable to bind nucleotide, can enhance ATPase activity in the neighboring TorsinA protomer in an unusual heterohexameric ring, via an arginine finger.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

    Jean-Ju Chung et al.
    A new component, CatSper zeta, is required for continuous alignment of the calcium channel along the sperm's tail and is crucial for normal sperm swimming behavior and fertility.
    1. Evolutionary Biology
    2. Neuroscience

    Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

    Luis Alfonso Yañez-Guerra et al.
    Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.
    1. Developmental Biology
    2. Evolutionary Biology

    Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

    Aaron L Fidler et al.
    Collagen IV is a primordial extracellular matrix component associated with the transition to animal multicellularity, and enabled the formation and evolution of epithelial tissues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert et al.
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

    Hermann Broder Schmidt, Dirk Görlich
    How nuclear pore complexes establish their permeability barrier has been a long-standing question; now, this process can be reconstituted by a surprisingly simple and rapid self-assembly of Nup98 FG domains into selective FG phases.
    1. Evolutionary Biology

    Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis

    Mayuko Hamada et al.
    The symbiotic relationship between Hydra and Chlorella is driven by metabolic co-dependence and characterized by changes in the photobiont genome in terms of lack of genes essential in free-living algae.

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