2,840 results found
    1. Ecology
    2. Evolutionary Biology
    Rat illustration

    The Natural History of Model Organisms: The Norway rat, from an obnoxious pest to a laboratory pet

    Klaudia Modlinska, Wojciech Pisula
    The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.
    1. Ecology
    2. Epidemiology and Global Health

    Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

    Cara E Brook et al.
    Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
    1. Cancer Biology
    2. Cell Biology

    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

    Jean M Mulcahy Levy et al.
    Pre-clinical and patient data show that inhibition of autophagy with an approved, inexpensive, well-tolerated drug can overcome resistance to BRAFV600E inhibition in multiple brain tumor subtypes with different resistance mechanisms.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Stem Cell Tumors: Cherub versus brat

    Jennifer A Malin, Claude Desplan
    A long non-coding RNA molecule called cherub is a driver of tumor development.
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    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen et al.
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Ecology

    Comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    Philip Dammann et al.
    We are writing to comment on the article by Ruby et al., 2018 about aging in naked mole-rats.
    1. Ecology

    Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'

    J Graham Ruby et al.
    We are writing to respond to the comment by Dammann et al., 2019 on our article about aging in naked mole-rats (Ruby et al., 2018).
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Cell Biology

    Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions

    Christina K Kim et al.
    SPARK2 allows a transcriptional readout of inter- and intracellular protein-protein interactions, with near-zero background, by employing proximity-dependent luciferase-LOV regulation.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.

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