5,397 results found
    1. Computational and Systems Biology

    A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity

    Barbara Bravi, Andrea Di Gioacchino ... Rémi Monasson
    An interpretable machine learning approach can recapitulate the molecular features associated to immune protein-protein binding and leverage them for the prediction of immune response specificity.
    1. Neuroscience

    A unified platform to manage, share, and archive morphological and functional data in insect neuroscience

    Stanley Heinze, Basil el Jundi ... Kevin Tedore
    The InsectBrain Database is a novel, freely available software tool designed to accelerate research in the field of insect neuroscience and to improve implementation of open data concepts.
    1. Genetics and Genomics

    Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity

    Stephen M Blazie, Seika Takayanagi-Kiya ... Yishi Jin
    The eIF3 translation initiation complex exerts specific regulation on neuronal protein levels by targeting mRNAs with GC-rich 5' UTR.
    1. Neuroscience

    Multi-contrast anatomical subcortical structures parcellation

    Pierre-Louis Bazin, Anneke Alkemade ... Birte U Forstmann
    An open-source software tool enables the anatomical parcellation of an unprecedented number of subcortical structures in magnetic resonance images of the human brain, automatically and in individual subjects.
    1. Computational and Systems Biology
    2. Neuroscience

    Inferring multi-scale neural mechanisms with brain network modelling

    Michael Schirner, Anthony Randal McIntosh ... Petra Ritter
    Hybrid brain network models predict neurophysiological processes that link structural and functional empirical data across scales and modalities in order to better understand neural information processing and its relation to brain function.
    1. Neuroscience

    Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children

    Chun Shen, Edmund T Rolls ... Jianfeng Feng
    Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.
    1. Genetics and Genomics
    2. Neuroscience

    Population clustering of structural brain aging and its association with brain development

    Haojing Duan, Runye Shi ... Jianfeng Feng
    Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.
    1. Neuroscience

    Model-based whole-brain perturbational landscape of neurodegenerative diseases

    Yonatan Sanz Perl, Sol Fittipaldi ... Enzo Tagliazucchi
    The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

    Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
    A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
    1. Computational and Systems Biology
    2. Developmental Biology

    Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain

    David M Young, Siavash Fazel Darbandi ... Stephan J Sanders
    A computational tool developed to construct three-dimensional anatomical atlases from two-dimensional data generates volumetrically complete and aligned atlases for all stages of development in the Allen Developing Mouse Brain Atlas.

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