1,768 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

    Rosa Maria Porreca et al.
    TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
    1. Chromosomes and Gene Expression

    RNase H enables efficient repair of R-loop induced DNA damage

    Jeremy D Amon, Douglas Koshland
    In addition to causing DNA damage, R-loops cause genomic instability by interfering with DNA repair.
    1. Chromosomes and Gene Expression

    DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Benjamin JM Taylor et al.
    Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.
    1. Chromosomes and Gene Expression

    Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

    Caroline Townsend Stork et al.
    The transcriptional response elicited by the hormone estrogen leads to DNA double-strand breaks by promoting R-loop formation in breast cancer cells.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation

    Rebecca Devlin et al.
    Mapping DNA replication timing, allied to genetic analysis of a RecQ repair helicase, reveals that antigenic variation in the African trypanosome may be initiated by locus-specific, replication-derived sequence instability.
    1. Cancer Biology

    Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

    Bente Benedict et al.
    During tumorigenesis loss of p53 not only abrogates cell cycle arrest and apoptosis, but also suppresses the induction of replication-stress-induced DNA double-stranded breaks.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Chromosomes and Gene Expression

    Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

    Bin-zhong Li et al.
    Genetic analysis combined with whole genome sequencing elucidates mechanisms and pathways that form and prevent a specific class of genome rearrangements, foldback inversions, seen in many human cancers.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MutSα maintains the mismatch repair capability by inhibiting PCNA unloading

    Yoshitaka Kawasoe et al.
    Biochemical analysis in Xenopus egg extracts reveals that the MutSα mismatch sensor retains the DNA-bound replication clamp to maintain a post-replicative temporal window permissive to strand-specific repair of mismatches.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Transposition-mediated DNA re-replication in maize

    Jianbo Zhang et al.
    Transposition reactions that occur during DNA replication and involve the termini of adjacent transposons can induce genome expansion by re-replication of transposon-flanking sequences.

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