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A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.

Metastases-associated fibroblasts show stage-dependent transcriptional plasticity and their rewiring is regulated by Myc.

ctDNA predict prognosis and treatment response of mTNBC patients more sensitively than traditional tumor markers, which implies ctDNA may be valuable for individualized treatment decision-making and paves the way for a non-invasive real-time clinical management strategy in patients with mTNBC.

Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.

Dalpiciclib could partially abrogate ER nuclear transportation induced by pyrotinib in HER2+HR+ breast cancer and CALML5 could serve as a potential risk factor in the treatment of HER2+HR+ breast cancer.

Modelled estimates for changes in cancer incidence, staging, and demand on health services are presented for a range of potential COVID-related disruptions to national population screening programmes for breast, cervical, and colorectal cancer, indicating markedly different impacts for each programme.

The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.

Stereotactic body radiotherapy combined with immunotherapy and chemotherapy in neoadjuvant setting exhibited a promising anti-tumor activity and an acceptable safety profile in triple-negative breast cancer patients.

Loss of RUNX1, a key regulator of estrogen receptor-positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

GrimAge acceleration may increase the risk of colorectal cancer.