123 results found
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki et al.
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt et al.
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies et al.
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Region-specific regulation of stem cell-driven regeneration in tapeworms

    Tania Rozario et al.
    Tapeworms grow and regenerate using stem cells distributed throughout their bodies, but their regeneration competence relies upon the unique micro-environment created by the head and neck.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

    Bo Wang et al.
    Cells that give rise to the infectious form of parasitic flatworms called schistosomes show similar patterns of gene expression to stem cells in free-living flatworms.
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Cancer Biology
    2. Cell Biology

    The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

    Nomeda Girnius et al.
    Mutational inactivation of the JNK signaling pathway causes genomic instability and breast cancer development.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe

    Marisa A Yonemitsu et al.
    A transmissible cancer that arose in a marine mussel spread from a single animal to become a global pathogen affecting two other mussel species in both Europe and South America.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu et al.
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.

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