424 results found
    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal et al.
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Neuroscience

    Opioids depress breathing through two small brainstem sites

    Iris Bachmutsky et al.
    Opioids stop breathing during overdose by silencing two small brain sites, with just 140 neurons in the breathing rhythm generator exerting the key effect.
    1. Computational and Systems Biology
    2. Neuroscience

    Mixed-mode oscillations and population bursting in the pre-Bötzinger complex

    Bartholomew J Bacak et al.
    Computational modeling reveals the mechanisms by which a diverse group of neurons in the brainstem generates rhythmic breathing in mammals.
    1. Neuroscience

    Opioids modulate an emergent rhythmogenic process to depress breathing

    Xiaolu Sun et al.
    Inspiratory rhythmogenesis is mediated by an emergent mechanism independent of bursts associated with motor output and is modulated by opioids, pointing to strategies for ameliorating opioid-induced respiratory depression.
    1. Neuroscience

    Interactions between respiratory oscillators in adult rats

    Robert TR Huckstepp et al.
    Active expiration in anesthetized rats is driven by the lateral parafacial region, but requires an additional form of excitation from another source.
    1. Computational and Systems Biology
    2. Neuroscience

    CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

    David Forsberg et al.
    Novel brainstem organotypic cultures that generate rhythmic respiratory motor activity reveal the neural networks that control breathing and a new pathway in the hypercapnic response.
    1. Computational and Systems Biology
    2. Neuroscience

    Brain Networks: Modeling breathing rhythms

    Jan-Marino Ramirez, Nathan A Baertsch
    Computational models are helping researchers to understand how certain properties of neurons contribute to respiratory rhythms.
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    1. Neuroscience

    Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network

    Marc Chevalier et al.
    Pacemaker neurons are present in the preBötC circuitry of mouse embryos and their role in driving respiratory network activity changes during the critical period immediately before birth.
    1. Neuroscience

    Absent phasing of respiratory and locomotor rhythms in running mice

    Coralie Hérent et al.
    When mice run, their breathing frequency increases but breaths are not temporally synchronized to strides at any speed or gait.
    1. Neuroscience

    Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

    Nathan A Baertsch, Jan-Marino Ramirez
    The neuromodulator substance P enhances mechanisms of recurrent excitation between breaths to control breathing frequency and stability.

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