63 results found
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

    Victor Ovchinnikov et al.
    Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structural basis for germline antibody recognition of HIV-1 immunogens

    Louise Scharf et al.
    Structural and computational analyses of germline antibody/HIV-1 gp120 complexes provide both general principles relevant to the unusual evolution of potent CD4-binding site antibodies and guidelines for structure-based immunogen design.
    1. Structural Biology and Molecular Biophysics

    Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

    Haoqing Wang et al.
    Single particle cryoEM structure of antibody complex with HIV-1 envelope trimer reveals new mode of asymmetric recognition of trimer apex.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Epitope resurfacing on dengue virus-like particle vaccine preparation to induce broad neutralizing antibody

    Wen-Fan Shen et al.
    Despite size heterogeneity, an epitope-resurfaced mature-form dengue VLP has the potential to induce quaternary structure-recognizing broad cross-reactive neutralizing antibodies.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A single, continuous metric to define tiered serum neutralization potency against HIV

    Peter Hraber et al.
    To quantify serum or antibody activity against HIV-1, logistic regression of single-dilution neutralization outcomes can efficiently summarize neutralization potency and indicate which samples may lack sufficient statistical support, for high-throughput screening in large-scale vaccine trials.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

    Angela M Phillips et al.
    Endoplasmic reticulum proteostasis factors enhance the mutational tolerance of influenza hemagglutinin, a model secretory pathway protein and therapeutic target, particularly improving the fitness of temperature-sensitive variants.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

    Bernard Khor et al.
    A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.
    1. Immunology and Inflammation

    CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

    Yosuke Kumamoto et al.
    CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.

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