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    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman et al.
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Developmental Biology
    2. Neuroscience

    Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

    Melinda S Modrell et al.
    An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
    1. Physics of Living Systems
    2. Neuroscience

    Direct mechanical stimulation of tip links in hair cells through DNA tethers

    Aakash Basu et al.
    The ability of hair cells to produce an electrical signal in response to a mechanical stimulus stems from tension in the elastic tip links within the bundles.
    1. Neuroscience

    Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function

    Bo Zhao et al.
    Super-resolution microscopy reveals a highly organized compartment in the stereocilia of mechanosensory hair cells of the inner ear, which is critical for hair cell function and affected in disease.
    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent et al.
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global biogeographic sampling of bacterial secondary metabolism

    Zachary Charlop-Powers et al.
    Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    An intracellular anion channel critical for pigmentation

    Nicholas W Bellono et al.
    Oculocutaneous albinism II (OCA2) contributes to a melanosome-specific anion channel that modulates organellar pH and is critical for melanin synthesis.
    1. Cell Biology

    Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration

    Risheng Ye et al.
    Under insulinopenic conditions, the hormone adiponectin is essential for lipid uptake specifically in subcutaneous white adipose tissue, and is sufficient to ameliorate islet lipotoxicity.
    1. Neuroscience

    Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

    Frederic A Roemschied et al.
    The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.