Under insulinopenic conditions, the hormone adiponectin is essential for lipid uptake specifically in subcutaneous white adipose tissue, and is sufficient to ameliorate islet lipotoxicity.
Oculocutaneous albinism II (OCA2) contributes to a melanosome-specific anion channel that modulates organellar pH and is critical for melanin synthesis.
An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
SKAP2 is critical for hematopoietic cell protection against Klebsiella infection in mouse lungs, for full phosphorylation of Src Family Kinases, Syk, and Pyk2, and for Klebsiella-induced reactive oxygen species production.
Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.
The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
Zebrafish mutants and human endothelial cell experiments reveal that GIPC family endocytic adaptors bind to the Semaphorin receptor PLEXIND1, a critical regulator of vascular development, to negatively modulate its signaling.
