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    1. Cancer Biology
    2. Cell Biology

    GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

    Jenna L Jewell et al.
    Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian target of rapamycin complex 1 (mTORC1) activity.
    1. Developmental Biology
    2. Neuroscience

    Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

    Melinda S Modrell et al.
    An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

    Giang T Nguyen et al.
    SKAP2 is critical for hematopoietic cell protection against Klebsiella infection in mouse lungs, for full phosphorylation of Src Family Kinases, Syk, and Pyk2, and for Klebsiella-induced reactive oxygen species production.
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman et al.
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Neuroscience

    Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

    Frederic A Roemschied et al.
    The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent et al.
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
    1. Cell Biology
    2. Neuroscience

    A feedback loop governs the relationship between lipid metabolism and longevity

    Nicole K Littlejohn et al.
    The dual control of adiposity and longevity emerges from a latent intestinal feedback loop which simultaneously augments fat loss and shields lifespan from the deleterious effects of continuous fat oxidation.
    1. Developmental Biology

    GIPC proteins negatively modulate Plexind1 signaling during vascular development

    Jorge Carretero-Ortega et al.
    Zebrafish mutants and human endothelial cell experiments reveal that GIPC family endocytic adaptors bind to the Semaphorin receptor PLEXIND1, a critical regulator of vascular development, to negatively modulate its signaling.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global biogeographic sampling of bacterial secondary metabolism

    Zachary Charlop-Powers et al.
    Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
    1. Neuroscience

    Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding

    Stuart L Johnson
    Mammalian primary sensory inner hair cells play an active role in auditory information processing, such that they show a preference for either timing or intensity coding.